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Abstract

ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF TAMARINDUS INDICA SEED COAT

Sirvi Someshver*, Sharma Urvashi, Dwivedi Sangeeta, Malviya Sapna and Kharia Anil

ABSTRACT

The aim of the present investigation is to evaluate the analgesic
activity of ethanolic extract of Tamarindus indica seed coat onWister
albino rat. Analgesic activity of the ethanolic extract ofTamarindus
indica (EETI) seed coat at a dose of 350mg/kg & 500mg/kg was
evaluated against the standard drug Pentazocine at a dose of 10mg/kg.
Adult Wister albino rat of either sex was divided in to 4 groups
comprising six numbers in each group was undertaken for study and
evaluated by tail flick method & hot plate method. The two doses of T.
indica seed coat ethanolic extract was found to produce significant (p <
0.05 and p<0.01) analgesic activity. In tail flick method, the crude
extract produced elongation of time 30 minutes after oral dose of 350
and 500 mg/kg body weight respectively. Test drug at a dose of 500mg
showed better analgesic activity in comparison to 350mg dose by both the methods. So, it can
be recommended for further studies.

Keywords: Analgesic, Tamarindus indica, Pentazocine, Ethanolic extract.


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