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Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELASE OF BUCCOADHESIVE BILAYERED BUCCAL TABLET OF NIFEDIPINE

Vineela Sangu*, R. Anusha Naik, Ajay Kumar D., B. Preethi Reddy and B. Dharani Priyanka

ABSTRACT

The aim of the present study was to design buccoadhesive bilayered tablets to release the drug unidirectionally in buccal cavity for extended period of time in order to avoid first-pass metabolism for improvement in bioavailability, to reduce the dosing frequency and to improve patient compliance. An attempt has been made to develop buccoadhesive bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer to release the drug for extended period of time with reduction in dosing frequency. Tablets of nifedipine were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, Methocel E15, and sodium carboxy methyl cellulose either alone or in combinations with backing layer of ethyl cellulose. The preformulation blend was shown good flow properties with good angle of repose, bulk density and tapped density parameters. The formulated tablets were evaluated for various quality control parameters and they were passed all the tests with standard values as per pharmacopoeia. Slow, controlled and complete release of Nifedipine over a period of 8 hours was obtained from matrix tablets formulated employing HPMC E15 and Carbopol 934P (F7 Formulation). This tablets exhibited good buccoadhesion. Good oral controlled released bilayered buccoadhesive tablet formulation of Nifedipine could be developed using HPMC E15 and Carbopol 934P.

Keywords: Nefidipine, Carbopol, Sodium CMC, Buccal tablets.


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