Abstract

INVITRO SCREENING OF ANTI-DIABETIC POTENTIAL OF MIRABILIS JALAPA FLOWERS AND ABELMOSCHUS ESCULENTUS LEAVES

Sunmathy Kanakamani, Saraswathi Uthamaramasamy* and Malathi Mangalanathan

ABSTRACT

Phytochemical analysis of Mirabilis jalapa revealed the presence of alkaloids, flavonoids, phenols, tannins, saponins and lignins. It is used in the treatment of skin disease, as an anti-pyretic and anti-parasitic. Abelmoschus esculentus is the only vegetable crop in Malvaceae family. It possess diuretic and demulcent property. The present study was done with an objective to explore the anti-diabetic property of Mirabilis jalapa (Flowers) and Abelmoschus esculentus (Leaves).The in vitro Anti-diabetic activity was done by inhibiting alpha-amylase, glucose diffusion and non-enzymatic glycosylation. The results of the study revealed that Mirabilis jalapa flower extract exhibited increased anti-diabetic activity at a concentration of 1000 g/ml than the leaves of Abelmoschus esculentus. From the observed results, it is concluded that Mirabils jalapa flowers are good source of phytochemicals which is responsible for its anti-diabetic activity.

Keywords: Abelmoschus esculentus, Anti-diabetic, Alpha-amylase inhibition, Glucose diffusion assay, Mirabilis jalapa.