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Abstract

DEVELOPMENT AND CHARACTERIZATION OF LULICONAZOLE ETHOGEL FOR TOPICAL USE IN THE TREATMENT OF ATHLETES FOOT INFECTION

Amit Kumar Rawat*, Naveen Gupta, Dr. Neeraj Sharma and Dr. Dharmendra Rajput

Abstract

Luliconazole is an imidazole antifungal agent with a unique structure, as the imidazole moiety is incorporated into the ketene dithioacetate structure. To develop and optimize the ethosomal formulation of luliconazole for Athlete’s foot infection. Characterization of optimized formulation in-vitro. To develop and characterize luliconazole ethosomes loded topical gel (Ethogel). Anti –fungal study of the optimized ethogel formulation. That ethosomes can become a promising drug carrier in future for not the only topical treatment of local and systemic disorders, but also for the cosmetic and cosmeceutical fields. The present study focused on development and characterization of LCZ loaded ethogel and their in incorporation in the topical gel to increase the permeation through stratum corneum, imparting controlled release as well as enhancing the hydration of the skin. Therefore, LCZ loaded ethosomes were prepared by Cold method with high-speed homogenization combined with ultra-sonication. The particle size was found to be in the range of 185 to 289 nm and a maximum of 93 % EE and -24.49 mV Zeta potential. ATR and XRD data ruled out any possible incompatibility among excipient. Release studies confirmed the sustain release nature of ethosomes.

Keywords: Luliconazole, Etheosome, Ethogel, Method of preparation.


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