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Abstract

FORMULATION AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF EZETIMIBE

Vishakha Vishwanath Doke*, Khemchand Gupta, Nilesh M. Khutle and Abhishek Desai

Abstract

The contemporary research was done with the goal of development and characterization of self-emulsifying drug delivery system of Ezetimibe (EZE) which is poorly water soluble and also to enhance its solubility in biological fluid, in order to improve dissolution as well as permeability which would lead to enhanced oral bioavailability of drug. Liquid SNEDDS (L-SNEDDS) was formulated using Capmul MCM C8 EP, Cremophore RH 40 and Labrafil M 2125 CS as oil, surfactant and co-surfactant respectively. Optimized L-SNEDDS formulation was found to be efficient with average %T of 99.5%, drug content of 98.43%, flask inversion 0 numbers, average particle size of 36.7 nm, zeta potential of -57.5 mV, Polydispersibility index in of 0.119. Also, the in vitro release profile of drug from L-SNEDDS encapsulated in hard gelatin capsules was evaluated in different dissolution media viz. simulated gastric fluid and simulated intestinal fluid. For the drug, more than 95% cumulative release was observed within 30 min exclusive of the pH of the medium. The L-SNEDDS were adsorbed on solid support and then mixed with tablet blends and compressed into tablets. Further, no adverse changes in globule size, shape, zeta potential of SNEDDS and dissolution profile were apparent on conversion to solid powder form and tablet form.

Keywords: Ezetimibe (EZE), Self nanoemulsifying drug delivery system (SNEDDS), liquid SNEDDS (L-SNEDDS), powder SNEDDS (P-SNEDDS) and Tablet SNEDDS (T-SNEDDS).


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