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Mohd Abdul Hadi1, Raghavendra Rao NG2*

1Dept of Pharmaceutics, Bhaskar Pharmacy College, Moinabad, R.R District, Hyderabad -500075, AP, India.
2Dept of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Karimnagar - 505481, AP, India.


Significant advances have been attained in developing and commercializing oral controlled release products. Many platforms are available for delivering small molecule drugs with good aqueous solubility in prolonged or delayed release forms. On the other hand, the continuous improvement of current delivery technologies is also important when it comes to decreasing cost and increasing efficiency. Those advancements include novel excipient, processes, and equipment as new tools formulation scientists can use to develop oral controlled-release formulations. In the present review article, the novel methods of preparing controlled or extended release formulations which can be successfully used in chronotherapy have been mentioned. These techniques also applied for drugs that require modification of drug release, masking of bitter taste, and protection of volatile substances. These technologies have also been found useful for timedrelease dosage forms, as timing release tablets, time clock system and delayed-release tablets. This article emphasis on the novel technologies such as capsule-in-a-capsule technology, tablet-in-a-tablet technology and tablet-in-a-capsule technology.

Keywords: Oral controlled-release formulations, Chronotherapy, Capsule-in-a-capsule technology, tablet-in-a-tablet technology, tablet-in-a-capsule technology.

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