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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL NARYLATED CHROMONES

Srinivas A., Hemasri Y. and Jaya Prakash Rao Y.*

ABSTRACT

A series of new N-arylated chromones were synthesized from 2-amino chromones and variety of aryl halides employing Pd-catalyzed Buchwald–Hartwig coupling The products may be used as precursors for synthesis of potentially relevant targets. The structures of all synthesized compounds were established based on IR, 1H NMR and 13C NMR and MS spectral analysis. The synthesized compounds were screened for their anti bacterial activity against gram positive bacteria B.subtilis and S.aureus, gram negative bacteria E.coli and P.aeruginosa, and anti fungal activity aganist A.niger and A.flavus. The compound 7g showed excellent activity against B subtitle and 7g, 7h exhibited promising anti fungal activity against A.niger.

Keywords: 2-Amino chromone, aryl halides, Buchwald–Hartwig coupling and N-aryl 2- amino chromones.


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