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Abstract

EFFECT OF SOLVENTS ON SPECTROPHOTOMETRIC ESTIMATION OF TINIDAZOLE IN BULK AND DOSAGE FORMS

L. Matsyagiri*, P. Jagadeesh, B. Mounika, V. Srinivas, V. Theja, Madhiha Jabeen and Dr. K. Hemamalini

ABSTRACT

Tinidazole is a synthetic antiprotozoal agent. It demonstrates activity both in vitro and in clinical infections against the following protozoa: Trichomonas vaginalis, Giardia duodenalis (also termed G. lamblia), and Entamoeba histolytica. A simple, sensitive, accurate and reproducible UV/visible spectrophotometric method were developed for the determination of Tinidazole in bulk and pharmaceutical dosage forms. Drug obeyed beer‟s law in the concentration range of 2-20 μg/ml. The method was validated for several parameters such as Linearity, Accuracy, Precision and Robustness as per the ICH guidelines. The drug exhibited maximum wavelength (nm) in 0.1N Sodium hydroxide solutions, 375 nm when compared with 0.1N Hydrochloric acid, Ethanol, and Distilled water due to the effect of solvent and chromophoric group. It was conclude that the drug, Tinidazole showed absorption maximum (λmax) in different manner in different solvents like 0.1N Hydrochloric acid, Ethanol, Distilled water and 0.1N Sodium hydroxide solution at 294 nm, 312 nm, 319 nm and 375 nm respectively. The percentage recovery values which is close to100 % indicates reproducibility of method and there is no interference from the excipients presents in the formulation (tablets) that developed method was found to be sensitive, accurate, and precise and the most reproducible result. The authors conclude that the proposed spectrophotometric method for the estimation of Tinidazole can be used for routine analysis of Tinidazole in bulk as well as in tablet dosage form.

Keywords: Tinidazole, UV Spectrophotometer, Validation, ICH guideline.


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