WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Lipimudra Padhy*, Ch. Niranjan Patra and Goutam Kumar Jena


Colorectal cancer is cancer that starts in colon and rectum. As the colon and rectum are the most interior part of gastrointestinal tract, it is a great challenge to target drug to colon and rectum for the local treatment of colorectal cancer. The aim of the current research was to develop Capecitabine loaded Eudragit S 100 nanoparticles for colorectal cancer targeting which would release drug neither in stomach nor in small intestine as Eudragit S 100 is a pH sensitive polymer, would release drug only in colorectal region. Six formulations of Capecitabine loaded Eudragit S100 nanoparticles with varying concentration of drug and polymer were prepared by nanoprecipitation method. The formulations were optimized in order to maximize % drug entrapment efficiency and minimize particles size. The optimized formulation was evaluated for % drug entrapment efficiency, zeta potential, particle size distribution, Fourior transform infrared (FT-IR) spectroscopy analysis, differential scanning calorimetry (DSC) study, transmission electron microscopy (TEM) analysis, in vitro drug release and cytotoxicities study using HT 29 cell lines and pharmacokinetic study by using rabbit model.

Keywords: Colorectal cancer; Eudragit S100; nanoprecipitation; pH sensitive polymer.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More