ANTICANCER EFFECTS OF GRAPE SEED EXTRACT ON HUMAN CANCER: A REVIEW
Purnima Baghel* and Anish Chandy
ABSTRACT
Purnima Baghel* and Anish Chandy
School of Pharmacy, Chouksey Engineering College Bilaspur (C.G.), India.
ABSTRACT
Grape seed extract (GSE) is a complex mixture of several compounds,
mostly represented by polyphenols and phenolic acids. Their
consumption is safe and is recognized to exert several and meaningful
health benefits. In particular, grape-related anti-tumoral activity
encompasses a wide array of biological mechanisms and cellular
targets, eventually leading to inhibition of cell growth and to enhanced
apoptosis in several cancer cell lines, including lung, colon, breast,
bladder, leukemia and prostate tumors. Those effects are likely
modulated at the molecular level through selectively modulating the
redox balance and displaying anti-oxidant as well as pro-oxidant
actions, according to the specific context. GSE-related anti-cancer
activity mostly relies on the induced increase in reactive oxygen species, followed by the
orchestrated down- and up-regulation of several key-molecular pathways, including MAPK
kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases. This review will
focus on Grape seed extract (GSE) may have a great relevance as source of potential new
pharmacological molecules, and could represent an important opportunity for clinical
research in the context of cancer.
Keywords: Grape seed extract (GSE), Apoptosis, Chemoprevention, and Oxidation.
[Full Text Article]