Abstract

STUDY OF ANTIOBESITY ACTIVITY OF WITHANIA SOMNIFERA ROOT AND TERMINALIA ARJUNA BARK IN MSG-HFD INDUCED MICE

Kumari Sangita*, Pattnaik Ashok, Chopra M P, Mohanty Satyajit,
Chakraborti Sanchari and K. B. Sulgana

ABSTRACT

Obesity is a major health problem. It is known for the risk factor for the development of many vital disorder. In this study, the methanolic extract of Terminalia arjuna and Ethyl acetate extract of Withania somnifera have been tested for their anti-obesity property. Animals treated with both plants have reduced the increase in body weight, periepididymal, fat weight etc. Antiobesity activity produced by plants are may be also because of inhibition of amylase enzyme, antioxidant activity, presence of tannins and flavonoid content. Before carrying out pharmacological activity preliminary phytochemical analysis was carried out. The plants have shown presence of some common constituents like saponins, flavonoids steroids tri-terpinoids glycosides and anthocyanins In this study, both plants are found be beneficial for the suppression of obesity and associated complications.

Keywords: Obesity, Withania somnifera, Terminalia arjuna, monosodium glutamate.