VALIDATION OF A MARKETED POLY HERBAL FORMULATION FOR ANTI-OBESITY ACTIVITY ON MONOSODIUM GLUTAMATE WITH HIGH FAT DIET INDUCED OBESITY
Satyajit Mohanty*, Ashok Pattnaik, Sangita Kumari, Sanchari Chakraborti
ABSTRACT
Obesity is a global epidemic and most common disorder in the world.
It continues to be a growing problem worldwide with no suitable
treatment options without side effects. The novel targets for antiobesity
activity includes 5-HT receptors, PPAR gamma receptor, PTP-
1B and pancreatic lipases. Traditional herbal medicines have more
acceptance than prescription drugs in many cultures with epidemics of
obesity. The herbal formulation were examined for the presence of
phytoconstituents, antioxidant activity, digestive enzyme activity,
hypoglycaemic effect, hypophagic effect & histology of adipose tissue
and fatty liver changes by using MSG-HFD induced obesity in Swiss
albino mice. In this study animal models for obesity were developed by
neonatal injections of monosodium L-glutamate and followed by high fat diet. Serotonin
level of brain extract was estimated using HPLC ECD instrument. In obese animal the
serotonin level was significantly less than the normal mice. After treatment both the test and
standard drug decrease the elevated serotonin level of the obese group which was accounted
for the decrease in food intake. Finally this report reveals the test drug (Medonil) showed
anti-obesity activity but it is not so significant as compared to the standard drug
(orlistat).However it was evident that food intake, adipose tissue weight reduced significantly
on treating with test compound drug (Medonil).
Keywords: Anti-obesity, Monosodium glutamate (MSG), High fat diet (HFD), PPAR gamma, Orlistat.
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