Abstract

VALIDATION OF A MARKETED POLY HERBAL FORMULATION FOR ANTI-OBESITY ACTIVITY ON MONOSODIUM GLUTAMATE WITH HIGH FAT DIET INDUCED OBESITY

Satyajit Mohanty*, Ashok Pattnaik, Sangita Kumari, Sanchari Chakraborti

ABSTRACT

Obesity is a global epidemic and most common disorder in the world. It continues to be a growing problem worldwide with no suitable treatment options without side effects. The novel targets for antiobesity activity includes 5-HT receptors, PPAR gamma receptor, PTP- 1B and pancreatic lipases. Traditional herbal medicines have more acceptance than prescription drugs in many cultures with epidemics of obesity. The herbal formulation were examined for the presence of phytoconstituents, antioxidant activity, digestive enzyme activity, hypoglycaemic effect, hypophagic effect & histology of adipose tissue and fatty liver changes by using MSG-HFD induced obesity in Swiss albino mice. In this study animal models for obesity were developed by neonatal injections of monosodium L-glutamate and followed by high fat diet. Serotonin level of brain extract was estimated using HPLC ECD instrument. In obese animal the serotonin level was significantly less than the normal mice. After treatment both the test and standard drug decrease the elevated serotonin level of the obese group which was accounted for the decrease in food intake. Finally this report reveals the test drug (Medonil) showed anti-obesity activity but it is not so significant as compared to the standard drug (orlistat).However it was evident that food intake, adipose tissue weight reduced significantly on treating with test compound drug (Medonil).

Keywords: Anti-obesity, Monosodium glutamate (MSG), High fat diet (HFD), PPAR gamma, Orlistat.