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Abstract

GENOTOXIC AND HEMOCHROMATOSIS EFFECT OF IRGASAN TREATMENT AND THE MITIGATING EFFECT OF VITAMIN E IN MALE ALBINO MICE

Sitanshu Mohan*, Debasish Pradhan

ABSTRACT

Several antimicrobial agents and preservatives (soaps, shampoos, detergents, disinfectants, cosmetics and pharmaceutical products) are commonly used in the personal care products. Different parts of our body like blood, milk, and various organs and tissues are the target of those chemical accumulations due to their continuous use with detectable concentrations. Irgasan (IGSN) is one of those antimicrobial agents that widely used as preservative in toothpastes, soaps, shampoos, and cosmetics and reported to be a highly toxic chemical for aquatic flora and fauna and thus has been included in the probable list of endocrine disruptors because of its resemblance with known non-steroidal estrogens or its mimetic. Furthermore, heat and ultraviolet irradiation convert IGSN and its chlorinated derivatives to various chlorinateddibenzo-p-dioxins that might be harmful for different biological systems. The mode of action of IGSN as an Endocrinedisrupting chemical (EDC) is controversial, in which IGSN exposure in Japanese medakafry (Oryziaslatipes) for fourteen days showed a weak androgenic effect. Another study reported that IGSN metabolite may be a weak estrogenic compound with the potential to induce vitellogenin while decreasing the hatchability, as well as delaying the hatching in females.IGSN has also been reported to inhibit testosterone-induced transcriptional activity as it functions as an anti-androgen agent. Exposure of IGSN to the human may be a consequence of its presence in the cosmetics and other human use products that could be absorbed mainly across the skin or through the gastrointestinal tract.

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