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Abstract

NANO DELIVERY: A SMART CARRIER FOR TREATMENT OF OVARIAN CANCER

Trilochan Satapathy, Suruj Kaushik*, Ashish Kumar Netam, Jhakeshwar Prasad, S. Prakash Rao, Mahendra Kumar Sahu, Purnima Baghel

ABSTRACT

Ovarian cancer ranks fifth globally among the causes of death for women and is the most lethal gynecologic cancer due to its high recurrence rate even though it is one of the most sensitive tumors, even at advanced stage. Despite improvements in the field of medicine, the reason for high mortality in ovarian cancer is late diagnosis because of nonspecific symptoms. The most significant reason for the recurrence of ovarian cancer is resistance by reducing cellular uptake, increasing elimination, inactivation/detoxification of drugs. Many efforts have been devoted to develop new treatment options due to the frequency of resistance. To overcome such problems various drug delivery and administration approaches have been developed. Numerous researches indicated that, nanotechnology was found to have advantages for molecular imaging, drug delivery, treatment and tumor targeting. Particulate drug nanocarriers such as liposomes, niosomes, polymeric micelles, solid lipid nanoparticles and polymeric nanoparticles have unique features for interacting with tumor microenvironments and tumor targeting as their submicron size. Nanotechnology-based drug delivery systems can be beneficial for the controlled delivery of chemotherapeutics by means of location and duration without undesirable side effects by overcoming several drug delivery barriers through passive or active targeting strategies.

Keywords: Ovarian cancer, Polymeric nanoparticles, Bioavailability, Drug resistance, Targeting.


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