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Somashekhar C. N.*, Shravya Lakshmi S., Prasad M. S., Poojashree P., Nithin Aradhya C. R. and Chethan J. P.


The Parenteral route of administration is the most common and efficient for delivery of active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. But parenteral route shows rapid action and rapid decline in systemic drug level. It is desirable to maintain systemic drug level within therapeutically effective concentration range. It requires frequent injection, which ultimately leads to patient discomfort. To overcome all these disadvantages in situ gel forming parenteral drug delivery system has been developed. In situ gel forming injectable drug delivery system is the ability to inject a drug incorporated into a polymer to a localized site and have the polymer form a semi-solid gel drug depot has a number of advantages. Among these advantages is ease of application and localized, prolonged drug delivery. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. It is an alternative to microspheres, liposomes and emulsion as parenteral depot systems. Hence in situ gelling polymeric delivery systems have been developed and investigated for use in delivering a wide variety of drugs including proteins. The production, packaging of such delivery system is less complex and hence reduce the manufacturing cost.

Keywords: Insitu gel, Mechanism, Natural Polymer, Method of Preparation, Evaluation.

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