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Abstract

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION FOR PROPRANOLOL AND HYDRALAZINE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING UV SPECTROSCOPY

H. Mamatha*, Mahesh M., C. Aswini, K. B. Chandra Shekar and Sridhar Thandra

ABSTRACT

Applying a simple technique of simultaneous equation and area under curve method by spectrophotometric. The aim of this study was to develop and validate with accurate, precision, reproducible and economical for simultaneous estimation of propranolol and hydralazine in bulk and marketed formulation. Maximum absorbance was shows at two different wavelengths of 289 nm and 314 nm that are the absorption maximum values of propranolol and hydralazine hydrochloride respectively in distilled water and it also used for baseline correction. In these methods, linearity range was 10-60μg/mL and 7-42μg/mL respectively for propranolol and hydralazine. The percentage RSD value was found to be less than 2%. The method was validated according to the ICH guidelines with respect to their parameters like specificity, linearity, accuracy, precision and robustness. The obtained result of analyses has been validated statistically. The method developed can be for the routine analysis of propranolol and hydralazine from their combined dosage form.

Keywords: Propranolol, Hydralazine, Simultaneous equation method and Area under curve, Spectrophotometric.


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