WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

RED PIGMENT EXTRACT OF SERRATIA MARCESCENS IS ABLE TO INDUCE CHANGE IN CANCER STEM CELL POPULATION (CD44 HIGH) OF METASTATIC PROSTATE CANCER CELL LINES DU145 & PC3.

Maithili A. Athavale*, Gayatri A. More, Smera Satish and Sangeeta A. Srivastava

ABSTRACT

Purpose: The aim of the study was to evaluate anticancer stem cell property of Red Pigment Extract (RPE) of Serratia marcescens on CD44 high cells of two breast viz. MCF-7, MDAMB231 and two prostate viz. DU145 and PC3 cancer cell lines. Methods: The effect of RPE of Serratia marcescens on breast and prostate cancer cell lines was checked by incubating breast (MCF7, MDAMB231) and prostate (DU145, PC3) cancer cell lines with RPE at inhibitory concentration 5 (IC5) for 72 hours at 370C, 5% CO2 in the respective cell culture media. The change induced by RPE on CD44 high cells was checked by Fluorescent Acquired Cell Sorter (FACS). Results: Our results indicated that RPE is able to induce change in CD44 high cells of only prostate (p<0.0001) but did not have much effect on breast cancer cell lines (p<0.05). RPE was able to shift CD44 high cells of prostate cancer to CD44 low CD24high thus making them susceptible to drug therapy. Conclusion: Findings of our study indicate that RPE of Serratia marcescens has a potential to inhibit cancer and cancer stem cells (CSCs) of metastatic prostate cancers and may act as a natural and cost effective source for cancer therapy.

Keywords: Red Pigment Extract (RPE), Serratia marcescens, Cancer stem cells, CD44 high, DU145, PC3.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More