CARDIOPROTECTIVE POTENTIAL OF TRIDAX PROCUMBENS AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN EXPERIMENTAL RATS
A. Shanmugapriya* and S. Maneemegalai
ABSTRACT
Myocardial infarction is one of the major killer diseases among
industrialized nations. Various medicinal plants are available that
exhibit potential cardioprotective properties. In the present study, the
ethanolic extract of Tridax procumbens in various concentrations were
studied for screening the cardioprotective activity against isoproterenol
induced myocardial infarction in albino rats. Serum marker enzymes
like Aspartate Transminase (AST), Alanine Transaminase (ALT), Acid
Phosphatase (ACP) and Alkaline Phosphatase (ALP), lipid profile,
lipoproteins were determined in serum of experimental animals. Since
the induction of Myocardial infarction is accompanied by the
generation of free radicals, the role of antioxidants in heart tissue has
been studied in experimental animals. The ethanolic extract of Tridax
procumbens showed significant cardioprotective effect by reducing the
level of biochemical parameters like marker enzymes, lipid profile and lipoproteins like LDL
and VLDL in increasing concentration. Treatment with Tridax procumbens considerably
restored the levels of antioxidants with increasing concentration. The results clearly
demonstrate that the active phytoconstituents present in Tridax procumbens ethanolic extract
protects myocardium against isoproterenol induced myocardial infarction.
Keywords: Ethanol, isoproterenol, antioxidants, myocardial infarction, markers.
[Full Text Article]