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Abstract

A COMPARATIVE STUDY ON DIFFERENT POLYMERS FOR THE PREPARATION OF FAST DISSOLVING ORAL FILMS OF LOPERAMIDE HYDROCHLORIDE

*K. P. Soorya and M. Gowtham

ABSTRACT

In the present work, aimed to a comparative study on different polymers for the preparation of fast dissolving oral films of loperamide hydrochloride as an anti-diarrhoeal drug using different ratios of polymers, Hydroxypropyl methylcellulose K 100 M, sodium carboxy methyl cellulose, poly vinyl alcohol cold as film forming agents. The film was prepared by solvent casting technique using propylene glycol as a plasticizer, sodium saccharin as a sweetener. The study examines about the effect of polymers ratio on physicochemical properties and drug release potential of films. All the films formulations (F1-F8) were evaluated for their thickness, weight variations, tensile strength, thickness, folding endurance, surface pH, in -vitro disintegration, drug content, In-Vitro drug release and stability study. The formulation, (F7) consisting of 130 mg of HPMC K 100 M, 150 mg of sodium carboxy methyl cellulose and 50 mg of poly vinyl alcohol cold was found to be best among all other formulations in the form of fast dissolving film based on the in vitro evaluation studies. The (F7) showed optimum disintegration time 50.33 ± 0.57 sec and percentage drug release 96.84± 0.79 %.

Keywords: Loperamide hydrochloride, HPMC K 100 M, SCMC, PVA cold, Solvent casting method.


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