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Abstract

IN VITRO ANTHELMINTIC ACTIVITY OF 3-(3-CHLOROPHENYL)-5- PHENYL-4, 5-DIHYDRO-1,2-OXAZOLE DERIVATIVES

V. Anitha Kumari*, K. Bharathi

ABSTRACT

Novel Isoxazoles are prepared by treating chalcone derivatives from 3- Chloro acetophenone with hydroxyl amine hydro chloride, small amount of sodium acetate and ethanol All the synthesised compounds were characterized by using the IR, H1 NMR spectroscopy. The Anthelmintic activity of compounds were tested at concentration of 20, 40, 80 mg/ml. In these the compound I-03 (3-(3-chlorophenyl)-5-(4- chlorophenyl)-4,5-dihydro-1,2-oxazole) shows better results than compare with the other compounds.

Keywords: isoxazoles, antihelmentic activity, hydroxyl amine.


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