EFFECT OF SIDA CORYMBOSA LEAF EXTRACT ON THE SERUM LIPID PROFILE LEVELS OF ALLOXAN-INDUCED DIABETIC ALBINO WISTAR RATS IN COLLEGE OF HEALTH SCIENCES AND TECHNOLOGY, NNAMDI AZIKIWE UNIVERSITY, NNEWI CAMPUS, ANAMBRA STATE, NIGERIA
Ogbodo Emmanuel Chukwuemeka*, Ezeugwunne Ifeoma Priscilla, Otuokwu Benice Chinwendu, Onyegbule Onyema Athanatius, Analike Rosemary Adamma, Amah Akuma Kalu and Oguaka Victor Nwabunwanne
ABSTRACT
This study was designed to investigate the effect of Sida corymbosa
(SC) leaf extract on serum lipid profile levels of alloxan induced
diabetic albino wistar rats. A total of 30 albino wistar rats each weighing
100g were assembled and divided into 3 groups (A-C) consisting of 10
rats each. Group A received SC treatment, B received ethanol treatment
while group C served as the control group. 400mg/kg of aqueous extract
of SC leaf was administered orally to the rats in group A, ethanol in
group B, while group C received only water for 7 days. Blood samples
were collected into plain containers for estimation of biochemical
parameters (TC, TG, LDL, and HDL) respectively. Serum TC, TG,
LDL, and HDL were analyzed using standard methods. There was a
significant decrease in the mean serum levels of TC, TG, and LDL
respectively after SC administration when compared with the control
group (P=0.000 respectively). Again, the result showed a significant decrease in the mean
weight of the rats post SC administration (P=0.000). However, there was a significant increase
in the mean serum level of HDL after SC administration when compared with the control group (P=0.000). This study revealed the hypolipidaemic effect of of SC use. Therefore, SC use could be of therapeutic importance in the prevention, and management of cardiovascular diseases.
Keywords: Sida corymbosa (SC), Total cholesterol (TC), Triglyceride (TG), Low density lipoprotein (LDL), High density lipoprotein (HDL), Weight.
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