Abstract

EFFECT OF SIDA CORYMBOSA LEAF EXTRACT ON THE SERUM LIPID PROFILE LEVELS OF ALLOXAN-INDUCED DIABETIC ALBINO WISTAR RATS IN COLLEGE OF HEALTH SCIENCES AND TECHNOLOGY, NNAMDI AZIKIWE UNIVERSITY, NNEWI CAMPUS, ANAMBRA STATE, NIGERIA

Ogbodo Emmanuel Chukwuemeka*, Ezeugwunne Ifeoma Priscilla, Otuokwu Benice Chinwendu, Onyegbule Onyema Athanatius, Analike Rosemary Adamma, Amah Akuma Kalu and Oguaka Victor Nwabunwanne

ABSTRACT

This study was designed to investigate the effect of Sida corymbosa (SC) leaf extract on serum lipid profile levels of alloxan induced diabetic albino wistar rats. A total of 30 albino wistar rats each weighing 100g were assembled and divided into 3 groups (A-C) consisting of 10 rats each. Group A received SC treatment, B received ethanol treatment while group C served as the control group. 400mg/kg of aqueous extract of SC leaf was administered orally to the rats in group A, ethanol in group B, while group C received only water for 7 days. Blood samples were collected into plain containers for estimation of biochemical parameters (TC, TG, LDL, and HDL) respectively. Serum TC, TG, LDL, and HDL were analyzed using standard methods. There was a significant decrease in the mean serum levels of TC, TG, and LDL respectively after SC administration when compared with the control group (P=0.000 respectively). Again, the result showed a significant decrease in the mean weight of the rats post SC administration (P=0.000). However, there was a significant increase in the mean serum level of HDL after SC administration when compared with the control group (P=0.000). This study revealed the hypolipidaemic effect of of SC use. Therefore, SC use could be of therapeutic importance in the prevention, and management of cardiovascular diseases.

Keywords: Sida corymbosa (SC), Total cholesterol (TC), Triglyceride (TG), Low density lipoprotein (LDL), High density lipoprotein (HDL), Weight.