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Abstract

SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM- A REVIEW

Rahevar Komal*

ABSTRACT

Oral route is the easiest and most convenient route of drug administration, but major problem encountered in oral formulations estimated 60-70% of new chemical entities exhibit poor aqueous solubility, because of their low bioavailability. The challenges task is to increase the bioavailability of drugs. Various strategies are reported in the literature including micronization, solid dispersions, cyclodextrines complex formation. Self micro-emulsifying drug delivery systems are usually used to improve the bioavailability of hydrophobic drugs. SMEDDS isotropic mixtures of oils, surfactants and co-surfactants and administered orally which on mild agitation with GI fluids forms o/w microemulsion. SMEDDS have enhanced bioavailability of drugs with reduction in dose and also drugs are protected from hostile environment in gut.

Keywords: Self microemulsifying drug delivery system (SMEDDS), surfactant, cosurfactant.


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