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Abstract

SYNTHESIS OF BIOLOGICALLY AND PHARMACOLOGICALLY ACTIVE DIHYDROPYRIMIDONES/THIONES: A REVIEW

Pritesh R. Jain and *Ashok A. Patil

ABSTRACT

The dihydropyrimidones/thiones (DHPM’s) and its derivative are an important class of organic as well as heterocyclic compounds. The chemistry of these compounds revised day by day because these are one of the most advantaged medicinal pharmacophore which appears as an important structural part in many naturally occurring and synthetically prepared medicinal drugs and heterocyclic compounds. Literature survey reveals that in the last few years many scientists, chemists and researchers are engaged in the synthesis of various types of dihydropyrimidones/ thiones and its derivatives as they having great biological and pharmacological activities. Generally synthesis of dihydropyrimidones/thiones involve one pot multicomponent reaction of various aldehydes, β- ketoester (1,3- dicarbonyl compound) and urea or thiourea.

Keywords: Synthesis of dihydropyrimidones/thiones, Lewis acids, multicomponent reactions.


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