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Abstract

PREPARATION AND EVALUATION OF BIPHASIC BILAYERED BUCCAL TABLET CONTAINING KETOROLAC IMMEDIATE RELEASE LAYER AND DOMPERIDONE MALEATE SUSTAINED RELEASE LAYER

M. Venkataswamy*, M. Santhoshini, J. P. Priyanka, K. Prathyusha, Jaggareddy Gari Manasareddy and Ramesh Alluri

ABSTRACT

In the present study an attempt was made to design a biphasic Bilayer buccal Tablet containing Ketorolac immediate release layer and Domperidone maleate sustained release layer. FT-IR studies reveal that there were no significant interactions between both the drugs and between the drugs and their respective excipeints. For achieving sustained release of Domperidone maleate, bucco adhesive polymers Carbopol and CMC were used Formulations D6 and D7 gave drug release 90.12±1.26 and 92.15±1.11 after 8hrs. Therefore D6 and D7 were considered as best formulations among D1 –D 11 for formulation of bilayer buccal tablets. For achieving immediate result of Ketorolac, from the results it was concluded that disintegration activity is good with Crospovidone and SSG, K6 releasing 100.05±1.2, K9 releasing 99.51±1.21% after 14min. The bilayered tablets prepared by taking D6 and D7 of Domperidone maleate and K6 and K9 formulations of Ketorolac as two layers (K6+D6, K6+D7, K9+D6, K9+D7) have shown good post compression parameters like hardness, friability weight variation, drug content etc which were within the limits. Hence they are considered as optimized formulations.

Keywords: Bilayer buccal Tablet, Domperidone maleate.


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