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Abstract

ANTI-CANCER ACTIVIY OF SORGAMARA ILAI CHOORANAM (LEAVES OF SIMAROUBA GLAUCA) IN IN-VITRO CELL LINE MODELS AGAINST INVASIVE CERVICAL CARCINOMA

Giftillda Selva Elsee T.* and Velpandian V.

ABSTRACT

Cancer is a class of disease characterized by out of control cell growth which tend to proliferate and in some cases to metastasize (spread), known medically as malignant neoplasm with a broad group by 100 different types. One of the Indian traditional systems of medicine, the Siddha medicinal system plays unique role in the treatment aspects of cancer. Siddha medicine, being the oldest traditional system in the world has a strong significance in detoxification, anti-oxidation, immune modulation and metabolic balance. It is a carefully guarded medical system given away incredible and rapid outcomes in various unremitting ailments. Among them Sorgamara Ilai chooranam (Simarouba glauca) is one of the herb mentioned in Siddha text with anticancer potential and is also considered being a crown of Siddha system of medicine Simarouba glauca also known as paradise tree has a long history of herbal medicine in many countries and belongs to the family Simaroubaceae. Simarouba glauca has 11 medicinally important quassinoids, the active principles in the tree. The Pharmacological activities are justified by anticancer effect on HeLa cell line study through in- vitro model. The main objective of this study was to evaluate the anticancer potential of Sorgamara Ilai Chooranam (leaves of Simarouba glauca) to treat cervical cancer. Anticancer activity of this Chooranam was evaluated in vitro for anticancer activity by MTT assay method in HeLa cell line. The results showed that the studied drug possessed relevant anticancer activity and thus, therapeutic potential in the treatment of cervical cancer.

Keywords: Anti-cancer activity, cervical carcinoma, Siddha herb, Simarouba glauca.


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