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Dinesh Yella, Sunanda Vemavarpu and Dr. Syeda Zaineb Humaira Hussaini*


Acebrophylline is used in the treatment of asthma and chronic obstructive pulmonary disorder. Acebrophylline is a widely prescribed oral bronchodilator with mucosecretolyic and anti-inflammatory activity. It works by relaxing the muscles of the airways and also thins and loosens mucus, making it easier to breathe. Side effects include Abdominal discomfort and distension, Flatulence, Nausea or Vomiting, Diarrhea, Heartburn, Gastrointestinal Bleeding, Difficulty in breathing, Skin rash, Increase in white blood cell count, Drowsiness, Swelling of the eyes, ears, and inside of nose, Fever with chills, Headache, Numbness of the hands, Sleeplessness, Increased heartbeat and weakness. A 60year old male visited to hospital with Complaints of worsening breathlessness and productive cough. His past medications include Budesonide and formetrol inhalation for acute exacerbation of COPD and oral phenytoin for Epilepsy. He was prescribed Acebrophylline(ABP) 200mg once daily after 3 days he presented with multiple erythematous wheals seen over back and shoulders associated with itching, ABP was stopped immediately and patient was treated symptomatically. This case is categorized as Probable as per Narinjos causality assessment scale.

Keywords: fixed drug eruptions, pharmacovigilance, Naranjo’s causality assessment scale, Acebrophylline.

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