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Abstract

ALFUZOSIN HCL FLOATING TABLET – FORMULATION AND EVALUATION

*V. Lokeswara Babu, N. Rajitha and A. Srinivasa Rao

ABSTRACT

The present work was to prepare and optimize floating tablet of Alfuzosin Hcl. Alfuzosin HCl is an alfa-1 adrenergic receptor blocker used for the treatment of benign prostatic hyperpleasia & hypertension which were design to increase the gastric residence time and thus prolonging the drug release. Alfuzosin HCL has the short biological half -life (3-5hrs) with dose range from 2.5mg thrice a day to maximum of 10mg once a day which results into inconveniency to the patients. By preparing the floating tablets of Alfuzosin HCl that delivers the drug for longer time, reduced dosage frequency & better patient compliance. The tablets were prepared by direct compression method by using different synthetic and natural polymers. All the batches were evaluated for pre compression & post compression parameters and results were observed within the limits. All the batches exhibited appropriate floating lag time with in prescribed limits. Formulation F13 was selected as an optimized formulation as it shown maximum % drug release at sustain rate at the end of 12 hours. Dissolution data were fitted to various kinetic drug release models.

Keywords: Alfuzosin HCl, Alpha adrenergic receptor blocker, biological half life, Floating tablets, direct compression, synthetic and natural polymers, floating lag time, optimized formulation.


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