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Ismail Khalid*, Gowtham M. and Vimal V.V.


The aim of this work was to develop a bioadhesive matrix tablet of poorly water soluble drug Miconazole Nitrate which is a broad spectrum imidazole antifungal agent used for treating candidiasis. An attempt was made to increase the solubility of the drug by forming a complex with water soluble polymer such as PEG 6000 using solid dispersion technique. Drug-excipients compatibility studies were performed by using FT-IR. The bioadhesive matrix tablets were prepared by direct compression method using different ratios of polymers like HPMC and Chitosan. The prepared tablets were evaluated for thickness, hardness, friability, weight variation, drug content, surface pH, bioadhesion strength, swelling index, ex-vivo residence time and in-vitro drug release. Among all the formulation, F2 was found to be the optimized formula as it possessed better post-compression parameters and in-vitro drug release profile. The optimized formula was subjected to stability studies to determine the physical stability of the formulation. Stability studies were carried out at 400C/75% RH for 1 month and no significant changes were identified during the study. In-vitro release kinetic studies showed that it fits well with zero order followed by Korsmeyer-peppas, Higuchi and release was found to follow non-fickian diffusion mechanism.

Keywords: Bioadhesive Matrix Tablet; Miconazole Nitrate; HPMC; Chitosan; Solid Dispersion; Direct Compression.

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