WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Nampelly Karnakar, Reddy Sunil*, Madireddy Mamatha and Anil Middha


The goal of the present investigation was to prepare and evaluate floating tablets of Metronidazole which is an Amoebicide inhibits the bacteria nucleic acid synthesis, used frequently in case of Amoebiasis, vaginitis, trichomonas infections, giardiasis, treponemal infections etc. Hydroxy propyl methyl cellulose (HPMC K4M, K15M, K100M) hydrophilic polymers used as control release of the drug, polyvinylpyrrolidine (PVP K30) used as binder, Microcrystalline cellulose (MCC) used as diluents, Sodium bicarbonate were used as source of carbon dioxide in effervescent tablets, Talc were used as glidant, Magnesium stearate used as lubricant. Three processes involved in the manufacturing of Floating tablets were direct compression, Dry granulation and wet granulation. The FTIR spectra of drug and different polymers showed no shift in peak, hence no interaction. Preformulation studies of drug and excipients were carried out and showed satisfactory results. The Floating tablets were evaluated for their hardness, friability, weight variation, thickness, assay, floating lag time, Total floating time and In-vitro dissolution. The in-vitro release study showed controlled and maximum drug release of 97.8%, 99.8%, and 95.1% within 12 hrs from formula F4, F7 and F9 respectively. Among these three formulations F7 shows least floating lag time of 84 sec and maximum drug release. The post FTIR spectra showed no shift in peaks. From the floating lag time data, release study and stability studies formulation F7 showed satisfactory results. Hence this study showed that direct compression is the best technique to formulate floating tablets.

Keywords: Metronidazole, floating tablets, Dry granulation, wet granulation, Direct Compression.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More