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Abstract

THYROXINE ACTIVITY OF PHYLLANTHIN & HYPOPHYLLANTHIN ON FEMALE & MALE WISTAR RATS

Prof, Dr. S. S. Agrawal, Tanya Kumar* and Mohd Mazhar

ABSTRACT

Hypothyroidism is the disease state in humans and animals caused by insufficient production of thyroid hormone. Hypothyroidism is treated with the levorotatory form of thyroxine (L-T4) and triiodothyronine (L-T3). But they may cause various side effects and may also be economically costly. Herbal drugs have been used since ancient time for curing various diseases. One such plant is Pyllanthus amarus, it is used as an hepatoprotective. Since, the liver metabolises the thyroid hormones T3 and T4; therefore, in a liver disorder the serum concentrations of both the thyroid hormones may be affected. Encouraging results were obtained when isolated compounds of Phyllanthus amarus viz., Phyllanthin and Hypophyllanthin showed thyroid activity quantified by inducing hypothyroidism in rats using chemical agents like Propythiouracil. Various parameters such as Total protein, total cholesterol, T3 and T4, TSH, daily food and water intake, histopathological parameters, reproductive hormones, weekly body weight, thyroid weight were estimated.

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