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Pragya Nayak*, Monica Kachroo, Priti Gupta and Fazlur Rahman


Thiazoles are important members of heterocyclic compounds It contains sulfur and nitrogen groups arranged in a heterocyclic ring system which imparts many biological activities such as antiinflammatory, antioxidant, anti tubercular, antibacterial activities. Many drug moieties are based on thiazole ring. Thiazolidinone have been considered as a magic moiety by many researchers because of its important contribution in the field of drug discovery and its property of possessing several various types of biological activities including antitumor activity. It has been a nucleus of interest because of its usefulness as intermediate for the synthesis of many new heterocyclic compounds. In the present study, an attempt has been made to incorporate both the potential rings in same compounds and to synthesize a series of new thiazolyl-thiadiazolidinone derivatives by cyclization of schiff base derivatives. The newly synthesized thiazolyl-thiadiazolidinone derivatives have been characterized by UV, IR, 1HNMR, 13CNMR, Mass spectra and elemental analysis and evaluated for their invitro anti-inflammatory and antioxidant activities. It was found that the derivatives containing methyl substitution has exhibited good anti-inflammatory and antioxidant activity at low concentrations as compared to the standard drugs.

Keywords: Thiazole; 1, 3-thiazolidin-4-one; antioxidant; anti-inflammatory.

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