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Abstract

DEVELOPMENT OF ISOSORBIDE MONONITRATE FAST DISINTEGRATING TABLETS AND CHARACTERIZATION

Nirupa S.* and Dr. K. Umashankar

ABSTRACT

In the present work, an attempt has been made to develop fast disintegrating tablets of Isosorbide mononitrate Novel method of co processed super disintegrates technology was employed to formulate the tablets using co processed polymers like vivasol, polyplasdone. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. then checked for compatibility using FTIR and DSC studies. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F14 formulation showed maximum drug release i.e., 99.3% in 4 min hence it is considered as optimized formulation. The F14 formulation contains CP5 as super disintegrate in the concentration of 40 mg. (CP 5 contains Vivasole and polyplasdone XL in 3:1 ratio).

Keywords: Isosorbide mononitrate, Co processed super disintegrates, Vivasole and polyplasdone XL.


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