WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

HPLC METHOD FOR DETERMINATION OF PARACETAMOL IN PHARMACEUTICAL FORMULATIONS AND ENVIRONMENTAL WATER SAMPLES

Nief Rahman Ahmad and Farha Khalaf Omar*

ABSTRACT

A simple, precise, rapid, and accurate reversed – phase high performance liquid chromatography method has been developed for the determination of paracetamol in pure from, pharmaceutical formulations and environmental water samples. Chromatography was carried out on supelco L1 (C18) reversed- phase column (25cm × 4.6mm), 5 microns, using a mixture of acetonitril : buffer pH3.0 (40: 60v/v) as a mobile phase at a flow rate of 1.5 ml.min-1. Detection was performed at 243nm at ambient temperature. The retention time was found 2.2 minutes. The calibration curve was linear (r= 0.999) over a concentration range from 10 to 100 μg/ml. Limit of detection (LOD) and limit of quantitation (LOQ) were found 3ng/ml and 9 ng/ml respectively. The method was validated for its linearity, precision and accuracy. The proposed method was successfully applied for the determination of paracetamol in pure form, pharmaceutical formulations and in environmental water samples.

Keywords: HPLC, Paracetamol, Pharmaceutical Formulations, Environmental Water Samples.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More