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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

siRNA-BASED NANOPARTICLES: A NOVEL APPROACH FOR GENE SILENCING TO ENHANCE CANCER THERAPY

S. M. Shatil Shahriar, Limana Afsarin Shammy, Mohammad Nazmul Hasan, Faozia Abida Islam Fariha, Tashfiqur Rahman, Nazmul Haque Jakir, Tanvir Islam and Md Nafiujjaman*

ABSTRACT

The anticancer activity of siRNA has been identified by researchers; more specifically; RNAi molecules like siRNA can silence onccogene expression that opens a new potential window in cancer treatment. It is considered as a new effective theme in cancer science owing to scientists can easily design siRNA molecules to suppress any kind of oncogenic proteins that have potential to cause cancer. In preclinical and clinical studies, various limitations have been arrived on account of their delivery barriers and unfavorable pharmacokinetics in biological environment. For example, blood nucleases degradation and quick renal clearance. In addition with, siRNA strongly weaken their cellular internalization from hydrophilicity and negative charge of naked siRNA. To surpass these bindings, development of appropriate delivery method is instantly required. To account these in thought, a carton of nanoparticles (NPs) have formulated that open a vast floor to substantially innovate the treatment strategy of cancer disease. Due to nanoparticle based drug delivery like NP-siRNA, the treatment approaches are more reliable than before. The purpose of this review is to pursue recent development in siRNA-based NPs, highlights preclinical and clinical studies and limitations that should be excelled for prospective new efficient therapeutics.

Keywords: RNAi, siRNA, Nanoparticles, Cancer Therapy, Priclinical Trials, Clinical Trials, Challenges.


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