A REVIEW ON MUCOADHESIVE AND BIOADHESION AS A NOVEL DRUG DELIVERY SYSYTEM
Warkari Rajan D., Nagoba Shivappa N.*, Shaikh Atiya L. and Wadulkar Ragunath D.
ABSTRACT
The current Review article has been focused on the mucoadhesive and
Bioadhesion drug delivery system may be designed to enable
prolonged retention at the site of application, providing a controlled
rate of drug release for improved therapeutic outcome. Drug actions
can be improved by new drug delivery system, such as mucoadhesive
system. This system remains in close contact with the absorption
tissue, the mucous membrane, releasing the drug at the action site
leading to improvement in both local and systemic effects. There are
many routes of mucoadhesive drug delivery system, oral route is the
most ancient as well as preferred by patient being convenient to take. However per oral route
has avoiding such as hepatic first pass metabolism and enzymatic degradation in GIT which
is a delay to the absorption of most proteins and peptides groups of drugs. Mucoadhesive
drug delivery systems interact with the mucus layer covering the mucosal epithelial surface
and mucin molecules and increase the residence time of the dosage form at the site of
absorption. The administration of drugs by the buccal route has several advantages over per
oral administration such as quick action, improved patient compliance particularly with
peadiatric & geriatric patient. The mucoadhesive ability of a dosage form is dependent upon a
variety of factors, including the nature of the mucosal tissue and the physicochemical
properties of the polymeric formulation.
Keywords: Muchoadhesion, Bioadhesion, Oral mucosa, buccal patch.
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