RECENT ADVANCE OF NANOTECHNOLOGY FOR THE TREATMENT OF OCULAR DISEASE
Meenakshi K. Chauhan and Geetanjali Khanna*
ABSTRACT
Nanoformulation are use as an alternative for traditional ophthalmic
formulation. Their are various factors that creats problem in treatment
of ocular disease like rapid elimination, enzymatic drug degradation,
Protein binding and physiological barrier etc. All these factors cause
reduction in intraocular residence time and poor bioavailability. Recent
research study shows that nanoformulation can enhance the therapeutic
efficacy and bioavailability of ocular drugs compared to conventional
ocular formulation. The various research study in number of patent
shows significant increase in therapeutic efficacy for various chronic
disease states of both anterior and posterior ocular segments. The
nanoformulation approach enhance the ocular bioavailability by
reducing the drug protein binding, increasing the corneal resident time,
enhancing the drug permeability and also providing a sustained drug
release. United States Food and Drug Administration (USFDA) has approved ocular drugs
employing nanotechnology and future developments.
Keywords: Ocular drug delivery system, Patent, Nanotechnology, United States Food and Drug Administration.
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