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Abstract

CLINICAL PROFILE OF ADVERSE CUTANEOUS DRUG REACTIONS AMONG PATIENTS VISITING DERMATOLOGY DEPARTMENT IN A TERTIARY CENTRE IN NORTH KERALA

Dr. Premkumar N., Dr. Bifi Joy, Dr. Usha Karunakaran, Charu Mohan* and Soniya S.*

ABSTRACT

Background: Adverse Cutaneous Drug Reactions (ACDR) is a major issue with drug therapy. The main intention of our study was to know more about the cutaneous adverse effects of drug that are commonly prescribed. Method: A cross sectional, observational study was carried out over a period of six months at Department of Dermatology, in Pariyaram medical college hospital, Kannur. The suspected ADRs were collected in patient profile form and evaluated by using severity by Hartwig and Siegel scale. Result: Total 55 patients were enrolled with 55 suspected ACDRs. During the study, 34 (61.82%) were males and 21 (38.18%) were females. Maximum number of cases were seen in the age group 19 - 64 years (65.45%) followed by the age group1– 12 years (16.36%), Maximum no. of cases occurred antibiotics (36.36%), NSAIDs (20%), anticonvulsant (14.54%), anticancer drugs (12.72%), antifungals, antiemetics (5.45%), PPIs, corticosteroids, Antiplatelets (1.81%). Maculopapular rash was the most common ACDR (n = 14, 25.45%), followed by fixed drug eruption (FDE) and Stevens- johnson syndrome (SJS) (n = 9, 16.36%), urticaria, acne, angioedema, Erythema multiforme were (n=3, 5.45%), hand foot syndrome, purpura, ACD, rash, xerosis (n=2, 3.63%). Of all the 55 cases, 20% were classified as mild (n = 11), 60% as moderate (n =33) and 20% as severe (n =11). Among the 55 patients under the study, about 44 (80%) were cured, 11 (20%) were improved. Conclusion: Adverse cutaneous drug reaction, more commonly occurred in patients taking medications such as antibiotics, NSAIDs, anticonvulsants, and anticancer drugs. Most common cutaneous drug reactions were maculopapular rash, followed by fixed drug eruption, Stevens - Johnson syndrome and urticaria.

Keywords: Clinical profile Adverse cutaneous drug reactions.


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