WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COMPARATIVE STUDY ON FORMULATION AND EVALUATION OF MICROEMULSION BASED GEL OF CURCUMIN WITH DIFFERENT COMBINATIONS OF POLYMERS

*Praveen Kumar and Dr. Rupa Mazumder

ABSTRACT

The present study was developed microemulsion based gel of curcumin polymer which will be useful in further drug delivery. The prepared microemulsion based gel was subjected to a various test like size distribution study, zeta potential, and soon. The microemulsion was clear, stable, an isotropic mixture of oil, water, and surfactant frequently in combination with a cosurfactant. It helps to solubilize the lipophilic drug moiety and had showed rapid and efficient penetration of the skin. The microemulsion had stability problem due to having low viscosity but can be overcome by incorporation into topical DDS causes improved viscosity and hydrating stratum corneum which increase dermal drug permeation and the skin flux. The Curcumin loaded micro-emulsion developed and optimized on the basis of Findings of physic-chemical characterization, was further loaded into the Carbopol 934 and HPMC gel base. The gel based micro-emulsion was expected to improve the overall pharmaceutical and pharmacokinetic features of the drug candidate in terms of ease of dermal application and improved transdermal drug penetration. The developed formulations were characterized by physic-chemical parameters such as globule size, zeta potential, viscosity, pH, FTIR studies, etc. The finding of FTIR studies released the absence of drug potential drug – excipient interaction and ruled out any possible physic-chemical incompatibility b/w curcumin and excipients. The proposed Curcumin loaded micro-emulsion was formulated using Castor oil as the oil phase, Tween 80 and methanol as Surfactant and co-surfactant respectively. Due to all these factors within the major group of semisolid preparations, the use of transparent gels has expanded in pharmaceutical preparations. In spite of the many advantages of gels, a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation microemulsion based approach being used so that even a hydrophobic therapeutic moiety can be successfully incorporated and delivered through gels. Hydrophobic drugs can be incorporated into the microemulsion based gel using drug/oil/water emulsions.

Keywords: .


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More