SCREENING OF THE ANTI-INFLAMMATORY ACTIVITY OF SIMAROUBA GLAUCA EXTRACT AGAINST FORMALDEHYDE INDUCED INFLAMMATION IN RATS
Nawres Taha Abdullah*, Nader Hamoud Khair and Raju Koneri
ABSTRACT
Objective: The aim of the current study was to evaluate in-vivo Anti-
Inflammatory activity of Simarouba glauca against formaldehyde
induced inflammation in Wistar albino Rats. Methods: The methanolic
exctract of Simarouba glauca was observed in formaldehyde (acute)-
induced hind paw oedema test in rats. The Simarouba glauca were
dried under shade and then powdered, and extracted with 90%
methanol by reflux. Preliminary phytochemical studies and acute
toxicity studies were also carried out. Inflammation was induced in the
left hind paw of Wistar rats by injecting 0.1 ml of 4% formaldehyde
solution below the plantar aponeurosis of the hind paw of the rats in
the last day of the experiment. Group 1 served as normal control while
group 2 was considered as disease control. Group 3 was standard receiving Diclofenac 10
mg/kg and Groups 4 and 5 disease animals were treated with Simarouba glauca (250 mg/kg
and 500 mg/kg respectively). The parameters included in this study was to observe the
inflammation of the paw edema of rats. Results: The present study demonstrated that
Simarouba glauca extract has an anti-inflammatory action against the acute phase of
inflammation using the Plethysmometer. Interpretation and conclusion: Significant Antiinflammatory
activity of Simarouba glauca observed in the present investigation could be the
result of reducing the inflammation. Methanolic extract of Simarouba glauca also showed
improvisation in reducing the inflammation and may have protective effect in Antiinflammatory
related complications.
Keywords: Simarouba glauca, Anti-inflammation, Formaldehyde, Plethysmometer.
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