EXTRACTION AND EXVIVO CHARACTERIZATION OF VARIOUS NATURAL MUCOADHESIVE POLYMERS
Pallavi K.*, Naveen Babu K. and M. V. Basaveswararao
ABSTRACT
A stable, non-toxic, economical and compatible dosage form can be
achieved with the right choice of the excipients. Use of natural
polymers instead of synthetic polymers, aids in the development of a
dosage form that is safer, with minimal side effects. The present study
envisaged the extraction of mucoadhesive polymers from natural
ingredients like Abelmoscusesculentus fruits, Hibiscus rosa-sinensis
leaves, Artocarpusheterophyllus fruit, Linumusitatissimum seeds and
Colocasiaesculenta corms. All the extracted mucoadhesives were
preliminarily evaluated using Molisch’s test, Iodine test, enzyme test
and Ruthenium test. Exvivo evaluation of extracted mucoadhesive was
executed using Wash off test performed using modified disintegration
apparatus and Mucoadhesive bond strength test performed using
modified digital balance apparatus. The results revealed that Linum
seed gum (M4) has highest mucoadhesive bond strength of 0.091N/m2 and a force of
adhesion 1.601 N followed by Artocarpus fruit gum (M3). Furthermore the results conclude
that the extracted mucoadhesive serve as a best alternative for the existing synthetic
mucoadhesives in formulating safer and cost effective dosage forms.
Keywords: Natural, Mucoadhesive, Extraction, Bond strength, Wash off test.
[Full Text Article]