DESIGN, DEVELOPMENT AND EVALUATION OF CHEWEABLE TABLETS OF METOPROLOL SUCCINATE BY WET GRANULATION METHOD
Dhanasure S. G.*, Dharashive V. M., Warad T. A. and Karale P. A.
ABSTRACT
Problems of swallowing and provides a quicker onset of action
overcomes by Cheweable tablets constitute an innovative excipients.
The bioavailability of some drugs may be increased due to absorption
of drugs in oral cavity. Cheweable tablets of Metoprolol succinate
prepared by wet granulation method using crospovidone as a super
disintegrants by wet granulation method. FTIR Spectroscopy was
carried out to determine the suitability of superdisintegrants with the
drug. The prepared fast dissolving tablets of Metoprolol succinate were
evaluated for post compression parameters. Metoprolol succinate is β1
selective (cardio selective) adrino rceptaor blocking agent. It is used as anti-hypertensive,
anti-anginal and in acute myocardial infarction. The bioavailability of the Metoprolol
succinate is about 40-50%, with 3-4 hr half life. In hypertension, it is given in 50 mg daily
and according to response the dose may increases to 400 mg. Hypertension is the most
common cardiovascular disease. The prevalence of hypertension increases with advancing
age Arterial pressure is the product of cardiac output and peripheral vascular resistance.
Drugs lower blood pressure by actions on peripheral resistance, cardiac output, or both.
Drugs may reduce the cardiac output by inhibiting myocardial contractility or by decreasing
ventricular filling pressure. Drugs can reduce peripheral resistance by acting on smooth
muscle to cause relaxation of resistance vessels or by interfering with the activity of systems
that produce constriction of resistance vessels (e.g., the sympathetic nervous system). In
patients with isolated systolic hypertension, complex hemodynamic in a rigid arterial system
contribute to increased blood pressure; drug effects may be mediated by changes in
peripheral resistance but also via effects on large artery stiffness. Metoprolol succinate, β1- selective adrenergic receptor blocking agent used in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction, heart failure, hyperthyroidism and in the prophylactic treatment of migraine.
Keywords: Cheweable, disintegrants, crospovidone, adrino rceptaor.
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