Abstract

DESIGN, DEVELOPMENT AND EVALUATION OF CHEWEABLE TABLETS OF METOPROLOL SUCCINATE BY WET GRANULATION METHOD

Dhanasure S. G.*, Dharashive V. M., Warad T. A. and Karale P. A.

ABSTRACT

Problems of swallowing and provides a quicker onset of action overcomes by Cheweable tablets constitute an innovative excipients. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity. Cheweable tablets of Metoprolol succinate prepared by wet granulation method using crospovidone as a super disintegrants by wet granulation method. FTIR Spectroscopy was carried out to determine the suitability of superdisintegrants with the drug. The prepared fast dissolving tablets of Metoprolol succinate were evaluated for post compression parameters. Metoprolol succinate is β1 selective (cardio selective) adrino rceptaor blocking agent. It is used as anti-hypertensive, anti-anginal and in acute myocardial infarction. The bioavailability of the Metoprolol succinate is about 40-50%, with 3-4 hr half life. In hypertension, it is given in 50 mg daily and according to response the dose may increases to 400 mg. Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age Arterial pressure is the product of cardiac output and peripheral vascular resistance. Drugs lower blood pressure by actions on peripheral resistance, cardiac output, or both. Drugs may reduce the cardiac output by inhibiting myocardial contractility or by decreasing ventricular filling pressure. Drugs can reduce peripheral resistance by acting on smooth muscle to cause relaxation of resistance vessels or by interfering with the activity of systems that produce constriction of resistance vessels (e.g., the sympathetic nervous system). In patients with isolated systolic hypertension, complex hemodynamic in a rigid arterial system contribute to increased blood pressure; drug effects may be mediated by changes in peripheral resistance but also via effects on large artery stiffness. Metoprolol succinate, β1- selective adrenergic receptor blocking agent used in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction, heart failure, hyperthyroidism and in the prophylactic treatment of migraine.

Keywords: Cheweable, disintegrants, crospovidone, adrino rceptaor.