WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF OLMESARTAN AND CILNIDIPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

*P. Adilakshmi, P. Venkateswara Rao, N. Srinivasa Rao and R. Dhana Lakshmi

ABSTRACT

A simple, accurate, precise method was developed for the simultaneous estimation of the Olmesartan and Cilnidipine in tablet dosage form. Chromatogram was run through Std BDS 150 x 4.6 mm, in the ratio 60:40 was pumped through the column at a flow rate of 1 ml/min. The buffer used in this method was 0.1%POA. The temperature was maintained at 30°C. Optimized wavelength selected was 210 nm. The retention time of Olmesartan and Cilnidipine were found to be 2.098 min and 2.928 min. %RSD of the Olmesartan and Cilnidipine were and found to be 0.2 and 0.2 respectively. %Recovery was obtained as 99.95% and 100.81% for Olmesartan and Cilnidipine respectively. LOD, LOQ values obtained from regression equations of Olmesartan and Cilnidipine were 0.01, 0.36 and 0.03, 1.09 respectively. Regression equation of Olmesartan is y = 22366x + 877.5, and y = 10431x + 4275 of Cilnidipine.. Retention times were decreased and the run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: Olmesartan, Cilnidipine, RP-HPLC, Validation, Method.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More