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Abstract

HEPATOPROTECTIVE POTENTIAL OF FICUS AURICULATA AND SARCOCHLAMYS PULCHERRIMA, TWO ETHNOMEDICINAL PLANTS USED BY THE MISHING COMMUNITY OF ASSAM

*B. K. Doley and B. B. Kakoti

ABSTRACT

Liver, the largest organ in the body is the major site of intense
metabolic activities. Toxicity to the liver by various agents has been
recognized as the major problem. Plant drugs practiced particularly in
certain communities are playing an important role and there is a
resurgence of interest in folkloric medicine for treatment of various
ailments including hepatopathy and other related diseases. In the study
the effect of Ficus auriculata and Sarcochlamys pulcherrima, were
evaluated in carbon tetrachloride induced hepatotoxicity in rats. Liver
necrosis was produced by administering carbon tetrachloride (CCl4, 1
ml/kg, 50% v/v with olive oil, i.p.) The liver damage was evidenced by
elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate
pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and Bilirubin. The pretreatment
of both the plant extracts (200 and 400 mg/kg, p.o.) significantly (P<0.001) reduced
CCl4 induced elevations of the levels of SGOT, SGPT, ALP and serum Bilirubin. Ficus
auriculata and Sarcochlamys pulcherrima, (400mg/kg, p.o.) and Silymarin (25mg/kg, p.o.), a
known hepatoprotective drug showed almost similar results exhibiting hepatoprotective effect
of the Plants.

Keywords: Hepatoprotection, Carbon tetrachloride, Silymarin.


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