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Dr. N. G. Raghavendra Rao and K. Divya


In present research work an attempt has been made to prepare mouth dissolving films of Losartan potassium which is a Angiotension II Type1 receptor Blocker used for the treatment of anti hypertensine. Losartan potassium is widely used as an antihypertensive drug, which is a potent drug candidate for developing in to Fast Dissolving Films. The fast dissolving films of Losartan potassium were prepared by solvent casting technique using film forming polymer HPMC, PVA. PEG is used as plasticizer. The compatibility of the drug in the formulation was confirmed by FTIR studies. FTIR studies reveal that there is no interaction between Losartan potassium and the excipients. The electron microscopy showed that the films are clear, colorless with smooth surface and little pores, without any scratches on the films. All the films prepared were evaluated for Physical appearance and surface texture, weight uniformity of films, thickness of the films, folding endurance, surface pH, drug content uniformity, in-vitro disintegration time of films, in-vitro dissolution Study and all the results were found to be satisfactory. The disintegration time decreased with increased in concentration of CCS, CP and SSG up to 6% w/w. Based on the in-vitro disintegration time, formulation FB2 were found to be promising and showed a disintegration time of 28 sec and showed drug release of 99.00% within 18 mins. The rapid increase in dissolution of Losartan potassium with the increase in CCS may be due to rapid swelling and disintegrating films rapidly. CCS was found to be the best among the three superdisintegrants. Based on the above results it can be concluded that the fast dissolving oral film of Losartan potassium may produce the rapid action thereby enhance the absorption by avoiding the first pass effect.

Keywords: Losartan potassium, HPMC, PVA, PEG, Crosscarmellose sodium, Sodium starch glycolate, Crospovidone, Disintegration time Fast dissolving films.

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