WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Kavitha M. K.*


Antifungal drug resistance is problematic as initial diagnosis of systemic fungal infection may be delayed and the choice of antifungal drugs remains limited due to the emergence of resistant fungal species. Four classes of antifungal drugs are most widely used in clinical practice to treat systemic fungal infections and there are four main antifungal drug targets in C.albicans. Antifungal drug resistance can be divided into two categories: clinical resistance and in vitro resistance. Mechanisms of antifungal resistance are either primary or secondary, and are related to intrinsic or acquired characteristics of the fungal pathogen that interfere with the antifungal mechanism of the drug. Resistance can also occur when environmental factors lead to replacement of a susceptible species with a resistant one. Most of the established antifungal resistance mechanisms are due to genetic mutation – usually point mutations in genes encoding drug targets or enzymes in metabolic pathways, or transcription factors leading to gene over expression. Such mutations are stable, take time to be acquired, and can be considered as long-term stress responses. Antifungal resistance has consequences associated with poor clinical outcome during antifungal treatment and prophylaxis. Strategies to overcome antifungal drug resistance include the synthesis of new drugs with better antifungal activity. In addition, antifungalcontrol programmes to avoid extensive and inappropriate use of antifungal may be needed. Early identification of Candida sp. from clinical specimens and standard antifungal drug susceptibility testing would be an effective approach for controlling outbreaks caused by C.albicans and Non albicans Candida species. Application of standard techniques, guidelines for the use of antifungal agents and control measures for predisposing factors may reduce the risk of drug-resistant Candida infections.

Keywords: Antifungal drug, drug targets, drug resistance, Candida sp.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More