PHYTOCHEMICAL ANALYSIS AND IN VITRO ANTIINFLAMMATORY ACTIVITY OF THREE INDIGENOUS PLANTS BY RBC MEMBRANE STABILIZATION METHOD
Asha Gangadharan* and Benny P. J.
ABSTRACT
The systematic evaluation of the anti-inflammatory activity of
indigenous plants used in wound healing will facilitate the
development of efficient wound healing drugs. The present study
was undertaken to evaluate the efficiency of anti-inflammatory activity
of three plants used by traditional healers, viz:- Hemigraphis colorata
(Blume) H.G. Hallier, Leucas aspera (Willd) Link and Biophytum
sensitivum (L.) DC. Hexane, ethyl acetate, acetone and ethanol extracts
of the plants, were subjected to evaluate Human RBC membrane
stabilization potential, which influence the process of inflammation.
Among the extracts screened the hexane and acetone extract of Leucas
aspera, acetone extract of Biophytum sensitivum and ethanol extract of Hemigraphis colorata
were exhibited significantly better activity than the other extracts and standard antiinflammatory
drug Diclofenac sodium. These observations will stimulate further research in
the clinical application of the plants under study. The study proves the anti-inflammatory
efficacy of the plants and they hold a good prospect for drug development against
inflammatory diseases.
Keywords: Hemigraphis colorata (Blume) H.G. Hallier, Leucas aspera (Willd) Link, Biophytum sensitivum (L.) DC, Anti-inflammatory activity and RBC membrane stabilization.
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