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Abstract

FORMULATION AND EVALUATION OF NICOTINE TRANSDERMAL PATCHES BY THE USING OF HYDROPHILIC AND HYDROPHOBIC POLYMERS

*D. Maheswara Reddy, V. Vijay Kumar, K. Pavan Kumar, P. Harshini, P. Lahari, C. Sunitha

ABSTRACT

The present investigation is to formulate matrix type Trans dermal drug delivery system of a Nicotine using different polymers such as Ethyl cellulose, Eudragit RL 100 by solvent evaporation technique. The prepared patches were evaluated by Compatibility study, Physical appearance, Thickness uniformity, Weight uniformity, Tensile strength, Folding endurance, Percentage Moisture content, Percentage Moisture uptake, Water vapour transmission rate, Drug content uniformity, In vitro drug release studies. From the results of the drug content determination, it was assured that there was uniform distribution of drug in the patches and the deviations were within the acceptable limits. Release study of Nicotine patches indicated that the drug release from the formulation varies with the different compositions of polymers. Among all the prepared formulations, formulation containing PVA and EC (1:1) showed better drug release of 76.76 ± 1.83 after 24 hrs. By reviewing the results obtained, on the basis of the in vitro characterization it was concluded that Nicotine can be administered transdermally through matrix type TDDS developed in our laboratory. Transdermal patches consisting of the polymers PVA and EC along with PEG 400 as plasticizer and Tween 80 as permeation enhancer demonstrated sustained release of the drug for 24 hrs.

Keywords: Transdermal Patches, Nicotine, Plasticizer, solvent evaporation method.


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