A PROSPECTIVE STUDY TO EVALUATE THE PRESCRIBING PATTERN OF DRUGS IN PATIENTS WITH ISCHEMIC STROKE AND ROLE OF MEMANTINE IN POST- STROKE APHASIA
Mathew George, Lincy Joseph and Reenu Elizabeth Varughese*
ABSTRACT
Stroke is a clinical syndrome characterized by rapidly developing
clinical symptoms and / or signs of focal, and at times global (applied
to patients in deep coma and those with subarachnoid hemorrhage),
loss of cerebral function with symptoms lasting for more than 24 hours
or leading to death, with no apparent cause other than that of vascular
origin. This was a prospective observational study, which included 63
patients who were admitted in Pushpagiri Medical College Hospital.
Patients prescribing pattern were evaluated from the case files and the
clinical outcome were evaluated by using National Institute of Heart
Stroke Scale (NIHSS) and Modified Rankin Scale (MRS). The
language function of the aphasic patients were assessed by using Benson’s classification and
their quality of life were evaluated by using Stroke Specific- Quality of Life (SS-QOL).
Majority of the stroke patients was prescribed with Antiplatelet, Neuroprotective,
Antihypertensive and Dyslipidemics. The clinical outcome, language function and quality of
life of the patients were improved, indicating the effectiveness of Memantine on the language
of post- stroke aphasic patients. The study confirm that post- stroke aphasia treatment with
memantine 5mg and 10mg could have significant valuable effects on the neurological
consequences of stroke and language function improvement of the study population.
Keywords: Stroke, Prescribing pattern, Incidence, Clinical outcome, Post-stroke aphasia, Memantine.
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