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Abstract

EVALUATION OF THE EFFICACY AND SAFETY OF COMPLEX THERAPY OF ACUTE RESPIRATORY DISEASES OF ADENOVIRAL ETIOLOGY IN YOUNG PEOPLE

Malyshev Nikolay Alexandrovich*, Lvov Nikolai Ivanovich and Maltsev Oleg Veniaminovich 

ABSTRACT

An important current epidemiological phenomenon is the simultaneous
circulation of different types and strains of viruses, including influenza
viruses, as well as the presence of mixed infections - influenza and
other acute respiratory viral infections in one patient. Adenovirus
infections occupy a leading position in the general structure of acute
respiratory viral infections, especially in periods when influenza rarely
occurs. Bearing in mind the particular clinical course of adenovirus
infection, the principal challenge of antiviral therapy, in addition to
relieving the manifestations at the height of the disease, is to suppress
adenovirus persistence and reduce the frequency of development of
late pneumonias and a protracted and recurrent clinical course. A
retrospective analysis of case histories where interferon inducers and
interferons were used to treat adenoviral diseases in young people
established that Kagocel, an inducer of the "late" interferons, significantly decreased the
incidence of pneumonia and a protracted and recurrent course compared with the baseline
(pathogenetic) therapy.

Keywords: Adenoviral disease, antiviral therapy, interferon, tilorone, meglumine acrid?nacetate, Kagocel.


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