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Abstract

SELF EMULSIFYING DRUG DELIVERY SYSTEM-A REVIEW

Pooja Chavan* and Sonali Hiranwar

ABSTRACT

Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. The primary mechanism of action, which leads to improved bioavailability, is usually avoidance, or partial avoidance, of the slow dissolution process, which limits the bioavailability of hydrophobic drugs from solid dosage forms. The unique feature of this delivery system is the ability to self-emulsify, that is, their ability to form micro emulsions or oil-in-water emulsions when diluted in the aqueous phase because of the gentle agitation of the gastrointestinal tract.

Keywords: Self emulsifying drug delivery system, bioavalability, lipophilic drug, cosolvent.


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